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α CTX-I // Alpha C-Terminal Crosslinked Telopeptide of Type I Collagen

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Biomarker Matrices: 

In bone, type I collagen constitute 90% of the organic matrix. Markers of bone resorption in serum or urine can be used to assess changes in bone resorption in various bone diseases or under treatment (Naylor and Eastell, 2012). Collagen in bone can be isomerized with racemization of the aspartic residues in the CTX telopeptide. The newly formed collagen is α isomerized and β isomerization occurs with aging (Garnero, 2012). In urine, the ratio between native and isomerized CTX can give an estimate of the extent of type I collagen isomerization in bone tissue (Cloos and Fledelius, 2000). Detection of α isomerized fragment in urine is an indicator of newly formed collagen degradation and can be used for detection of bone metastases or Paget’s disease and follow up of treatments. Detection of β isomerized fragments in urine or serum is an indicator of mature bone collagen degradation, like in osteoporosis.

Different manual or automated sandwich immunoassays for CTX-I with α or β isomerization are validated in Bioclinica Lab for measurement in urine or serum matrix. Results in urine are normalized with values of urine creatinine.

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