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Aβ 1-40 // Beta Amyloid 1-40

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Amyloid β1-40 is one of the fragments generated after cleavage of the amyloid peptide precursor protein by β and γ secretases. This fragment is also among the most abundant variant of amyloid β peptide found in the cerebrospinal fluid (Portelius et al., 2006; Vigo-Pelfrey et al., 1993). In association with the Aβ1-42 measurement, Aβ1-40 allow normalization of high Amyloid producers in the diagnosis and follow-up of Alzheimer’s Disease (Dorey et al., 2015; Dumurgier et al., 2015).

Bioclinica Lab employs a manual sandwich ELISA for the measurement of Aβ1-40 in human cerebrospinal fluid.


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