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Aβ 1-42 // Beta Amyloid 1-42

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Amyloid peptides are produced during neuronal activity. Amyloid precursor protein is first cleaved by β secretase-1 (BACE-1) and then by γ secretase. When the concentration of Aβ1-42 is high, there is an increased propensity of amyloid plaques formation (Braak et al., 2013; Lührs et al., 2005). Accumulation of extracellular plaques of amyloid is one of the features of Alzheimer's disease, detection of these plaques in PET imaging and indirectly with reduced Aβ1-42 levels in cerebrospinal fluid is indicative in the diagnosis of Alzheimer's disease(Blennow et al., 2015; Palmqvist S et al., 2014).

Bioclinica Lab employs a manual sandwich ELISA for the measurement of Aβ1-42 in human cerebrospinal fluid.

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