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CGA // Chromogranin A

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Chromogranin A (CGA) is a neurosecretory protein initially identified in bovine adrenal medulla and produced simultaneously with catecholamines (Banks and Helle, 1965). CGA is the pro-hormone of at least three biologically active peptides generated by proteolytic cleavages: vasostatin, pancreastatin and parastatin, and also of two other peptides with antimicrobial and antifungal activities (catestatin and chromofungin). CGA circulates at low levels in normal subjects and elevated serum levels have been found in patients with neuroendocrine tumors, renal failure, hypertension, some inflammatory diseases, sepsis and subjects treated with proton pump inhibitors (Angelone et al., 2012; Helle and Corti, 2015).

Bioclinica Lab employs a manual sandwich radioimmunoassay designed for the measurement of whole and fragmented Chromogranin A in serum.

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