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COL4 // Type IV Collagen

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Type Collagen IV is encoded by six genes: COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, and COL4A6 for the six collagen chain implicated in its composition: α1(IV) through α6(IV). The assembly of collagen IV network is highly regulated. Each of the six chains present the same features with three domains: short 7S N-Terminal, collagenous domain and non-collagenous domain (NC1) in C-terminal and can form three sets of helical molecules. Depending on the tissues the set of collagen type IV molecules is different. The α1.α1.α2(IV)-α1.α1.α2(IV) network is found in all basement membranes in the animal phyla, the α3.α4.α5(IV)-α3.α4.α5(IV) and the α1.α1.α2(IV)-α5.α5.α6(IV) are only found in mammalian basement membranes (Hudson et al., 2003). NC1 trimers also connect to form hexameric quaternary structure through head to head interaction and the collagen IV network is also formed through protomer-protomer interactions in the collagenous and covalent binding in the 7S domain (with four independent protomers)(Cummings and Hudson, 2014). Elevated serum and/or urinary content in Collagen IV can be found in patient with diabetic nephropathy and in some cancers (Banu et al., 1995; KINOSHITA et al., 2010; Nyström et al., 2015).

Bioclinica Lab employs a manual sandwich immunoassay for the measurement of Collagen IV in serum, plasma or urine.

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