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COMP // Cartilage Oligomeric Matrix Protein

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Cartilage oligomeric matrix protein (COMP) is also called thrombospondin-5 (TSP-5). COMP possess a RGD motif which allow interaction with integrins (Tan et al., 2009). COMP can bind to chondrocytes (the only cell type found in cartilage) and promote early stages of chondrogenic differentiation of mesenchymal stem cells, in association with bone morphogenic protein-2 (BMP-2)(Chen et al., 2005). Serum COMP is elevated in patients with diagnosed OA (level of evidence grade C) (Hoch et al., 2011).

Bioclinica Lab employs a manual immunoassay validated in the laboratory for measurement of COMP in serum and synovial fluid.

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