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CS846 // Chondroitin Sulfate 846 Epitope

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Chondroitin Sulfate epitope 846 (CS846) is an epitope present in newly synthetized agreccan molecules. CS846 is increased in joints and synovial fluid of patients with rheumatoid arthritis or osteoarthritis (Lohmander et al., 1999; Rizkalla et al., 1992; Verstappen et al., 2006). These increased levels in serum may reflect pathological increase in turnover of newly formed matrix, something that is not seen in healthy adult cartilage. To date, serum CS846 is also one of the 12 best-qualified biochemical markers that have shown associations with osteoarthritis (Hunter et al., 2014).

Bioclinica Lab employs a manual competitive immunoassay for the measurement of CS846 epitope in serum.


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