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CTX-II // C-Terminal Telopeptide of Type II Collagen

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Type II Collagen is the predominant collagen in cartilage and is degraded by proteolytic enzymes secreted by the chondrocyte and synoviocytes. CTX-II peptides, released from the action of these enzymes, are eliminated in urine. Urine CTX-II is thus a biochemical marker of cartilage degradation (Garnero et al., 2000).

Bioclinica Lab employs a competitive assay for the measurement of CTX-II. This assay is  specific for the EKGPDP peptide derived from collagen type II C-telopeptide (monoclonal antibody MAb F2603) and did not recognize peptides from the N-telopeptide of collagen type II or from other collagen types (Christgau et al., 2001). The assay is designed to measure CTX-II in urine samples only.


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