Please Wait...

CTX-II // C-Terminal Telopeptide of Type II Collagen

Biomarker Therapeutic Areas: 
Biomarker Matrices: 

Type II Collagen is the predominant collagen in cartilage and is degraded by proteolytic enzymes secreted by the chondrocyte and synoviocytes. CTX-II peptides, released from the action of these enzymes, are eliminated in urine. Urine CTX-II is thus a biochemical marker of cartilage degradation (Garnero et al., 2000).

Bioclinica Lab employs a competitive assay for the measurement of CTX-II. This assay is  specific for the EKGPDP peptide derived from collagen type II C-telopeptide (monoclonal antibody MAb F2603) and did not recognize peptides from the N-telopeptide of collagen type II or from other collagen types (Christgau et al., 2001). The assay is designed to measure CTX-II in urine samples only.

ADDITIONAL RESOURCES

Biomarker Menu

Download MENU

Molecular Marker Laboratory Services

Download Brochure

Alzheimer's Disease Biomarker Lab Expertise

Download Info Sheet

Leader in Clinical Trial
Management Solutions

Successful clinical trials require the ability to see key details and uncover hidden insights. Bioclinica utilizes science and technology to bring clarity to clinical trials, helping companies to develop new life-improving therapies more efficiently and safely.

We're hiring recent tech grads in #RTP for #pharma sector! Our innov. clinical financial solution gives our client… https://t.co/GHgOfszO0T
bioclinica (3 hours ago)
Great to be @DrugInfoAssn DIA China! Ask us @bioclinica how sponsors & CROs can optimize electronic data capture… https://t.co/TtE4AiLnqY
bioclinica (9 hours ago)
RT @bioclinica: Kinks in the clinical supply chain? Check out how one of our clients is using clinical supply optimization technology for m…
bioclinica (9 hours ago)
RT @bioclinica: Welcoming everyone to KOP for #OCTEast Coast!!
bioclinica (9 hours ago)
Welcoming everyone to KOP for #OCTEast Coast!!
bioclinica (Yesterday)
Case processing is an important aspect of post-marketing drug safety surveillance. Here's a case study showing how… https://t.co/UMYp92Puvc
bioclinica (2 days ago)

Latest Blogs:

Latin America: Benefit from the Right Partner
Removing Risk from Clinical Trial Management System (CTMS) Implementations
Collaboration Between Clinical Operations and the Logistics and Supply Chain Teams is Key to Trial Success
The Value of Protocol Review
CTMS and RBM: Hot Topics at OCT Nordics in Copenhagen