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DKK-1 // Dickkopf Related Protein-1

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Dickkopf family members are involved in the modulation of Wnt signaling. DKK1, the first member of this family (which comprises at least 4 cystein-rich protein), is an inhibitor of Wnt signaling. DKK1 has been found to not only promote bone resorption in a mouse model of arthritis but also to block bone formation and repair of diseased joint (Diarra et al., 2007). DKK1 appeared as a central player in bone homeostasis with implication in bone development and maintenance of bone mass as well as in formation of bone metastases (Pinzone et al., 2009).

Bioclinica Lab employs two manual immunoassays for the measurement of DKK1; one is dedicated to measurements in plasma EDTA and the second to measurements in serum.

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