Ferritin is a ubiquitous and specialized protein implicated in the intracellular storage of iron. In mammals, ferritin is composed of 24 subunits forming a hallow globular complex whose cavity can store up to 4500 iron atoms (Finazzi and Arosio, 2014). Ferritin-mediated iron storage involves an oxidation process ̶ conversion of Fe(II) to Fe(III) ̶ that protects cells from the generation of toxic reactive oxygen species (Recalcati et al., 2008). The iron stored in the ferritin cavity is readily available for high iron demands. Ferritin is mainly localized in the cytoplasm but trace amounts are found in serum, where it is used as an indicator of body iron stores.
Bioclinica Lab employs a quantitative immunoturbidimetry method for the measurement of Ferritin in human serum.
Finazzi, D., and Arosio, P. (2014). Biology of ferritin in mammals: an update on iron storage, oxidative damage and neurodegeneration. Arch. Toxicol. 88, 1787–1802.
Recalcati, S., Invernizzi, P., Arosio, P., and Cairo, G. (2008). New functions for an iron storage protein: the role of ferritin in immunity and autoimmunity. J. Autoimmun. 30, 84–89.