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Fetuin-A

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Fetuin A, also known as α-2-HS glycoprotein (AHSG) is a well conserved glycoprotein implicated in the regulation of phosphorus and calcium homeostasis. Fetuin-A has also a role in inflammation and metabolic disease as it binds to minerals, lipids, lectins, proteases and has TGF-β antagonist and insulin receptor antagonist action. Fetuin A is synthetized by the liver and circulates in blood at high concentrations. For example, fetal calf serum contains less albumin than fetuin-A (Jahnen-Dechent et al., 2011). Fetuin-A is also present in calciprotein particles (cytotoxic particles containing inorganic calcium-phosphate crystals and mineral binding proteins) in patient with chronic kidney diseases (Kuro-o, 2013).

Bioclinica Lab employs a manual sandwich immunoassay designed for the measurement of Fetuin A in serum.

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