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HA // Hyaluronic Acid

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Hyaluronic acid (HA) is also known as hyaluronate or hyaluronan. This macromolecule is a ubiquitous linear polymer, especially abundant in connective tissues. HA is synthetized in the plasma membrane by a membrane-bound protein by addition of sugar units (D-glucuronic acid and D-N-acetylglucosamine, linked via alternating β-1,4 and β-1,3 glycosidic bonds) from a nucleotide precursor and followed by translocation to the extracellular space (Fraser et al., 1997). HA found in low concentration in blood comes from the peripheral tissues through the lymph and in physiological condition is rapidly took up and degraded by the liver. In patients with liver diseases, such as liver cirrhosis, increased serum levels of HA have been found. Increased blood levels can also be the result of inflammatory condition such as rheumatoid arthritis, psoriasis and scleroderma (Laurent and Fraser, 1992).

Bioclinica Lab employs a sandwich protein binding manual assay, which use Hyaluronic Acid Binding Protein for the capture and detection of HA. This assay is designed for the measurement of Collagen IV in serum.

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