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IGF-1 // Insulin-Like Growth Factor I or Somatomedin C

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Insulin Like Growth Factor 1 (IGF-1) and 2 (IGF-2) are produced mainly by hepatocytes, and to a lesser extent in other tissues (Ranke, 2015). IGF-1 and IGF-2 have structural and sequence homology with insulin and also shared some biological functions. These hormone were assigned in 1978 to the family of somatomedins (Rinderknecht and Humbel, 1978a, 1978b). Higher risks of cancer were found to be associated with high IGF-1 levels in serum. This can be the result of IGF-1 influence on epithelial-cell population renewal rates and of its anti-apoptotic effect (Pollak et al., 2004). IGF-1 circulates as a ternary complex with Acid Labile Subunit (ALS) and IGF-Binding Proteins (IGFBPs) and less than 1% is free. As a direct mediator, non-affected by diurnal fluctuation, serum IGF-1 reflect the levels of Growth Hormone (GH) and is used in the diagnosis of a wide range of diseases arising from GH deficiency or excess (Ketha and Singh, 2015).

Bioclinica Lab employs a manual sandwich radioimmunoassay for measurement of IGF-1 in serum.


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