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IGFBP-3 // Insulin-Like Growth Factor Binding Protein 3

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The majority of Insulin Like Growth Factors (IGFs) in serum is complexed with IGF Binding Proteins (IGFBP) and acid-labile subunit (ALS). Six IGFBPs have been cloned and identified. IGFBP3 has the highest binding capacity for IGF-1 and it prolonged its high life in serum. GFBPs in serum regulate the endocrine actions of IGFs by modulating bioavailable IGF (Mohan and Baylink, 2002). IGFBPs constitute a "buffer" capable of limiting the effect of a rise in IGF concentration (which could result in hypoglycemia) (Ranke, 2015). IGFBP3, through its binding with IGF-1, can also have a role in cancer cell growth and proliferation through a possible potentiation of IGF-1 signaling (Baxter, 2014).

Bioclinica Lab employs a high sensitive manual sandwich immunoassay for measurement of IGFBP3 in serum.

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