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IL-18 // Interleukin 18

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Interleukin 18 (IL-18) belongs to the IL-1 family and is produced by macrophages, dendritic cells and epithelial cells (keratinocytes). Pro-IL-18 is expressed constitutively and is then activated by caspase 1. Its receptor is IL-18R and the pro-inflammatory signaling requires the formation of a complex containing IL18, IL18R and IL-18RAP (Sims and Smith, 2010). In normal condition, IL-18 activity is lowered by high levels of IL-18 Binding Protein (IL-18BP). Binding of IL-18BP to IL-18 prevents its interaction with IL-18R. The ratio IL-18BP/IL-18 is altered in inflammatory conditions (Liang et al., 2006). Elevated levels of IL-18 have also been found to have a pertinent prognostic value in predicting cardiovascular mortality in patients with chronic kidney disease (Formanowicz et al., 2015).

Bioclinica Lab employs a manual sandwich immunoassay for the measurement of IL-18 in serum.

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