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IL-6 // Interleukin 6

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Interleukin 6 (IL-6) was initially identified as a differentiation factor for B-cells and was then named: B-cell stimulatory factor 2 (Naka et al., 2002). IL-6 is a pleiotropic cytokine produced by different types of cells (T cells, B cells, monocytes, fibroblasts, keratinocytes, endothelial cells, mesangial cells and some tumor cells). This cytokine has also a wide range of effect on different target through trans- or classical signaling with the IL-6R system (Calabrese and Rose-John, 2014). This signaling is conditioned by the association of IL-6R (soluble or non-soluble) and IL-6 with two molecules of glycoprotein 130 (gp130). Dysregulation of IL-6 contribute to a wide range of diseases (rheumatoid arthritis, systemic sclerosis, Crohn’s disease, Systemic lupus erythematosus and in tumor progression) (Yao et al., 2014).

Bioclinica Lab employs a high sensitive manual sandwich immunoassay for measurement in serum.

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