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OPG // Osteoprotegerin

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Osteoprotegerin (OPG) is a secretory glycoprotein composed of 401 amino acids (mature form with 380 amino acids) and seven structural domains. OPG exists as a disulfide-linked homodimer or as a monomer (Simonet et al., 1997). OPG belongs to the TNF receptor superfamily and was initially described as a cytokine, binding essentially the Receptor Activator of Nuclear Factor κβ Ligand (RANKL).Since, OPG have been found to be implicated in other pathways (Baud’huin et al., 2013). In addition to its implication in bone metabolism, OPG have been associated with diabetes of types 1 and 2, obesity metabolic syndrome, atherosclerosis and hypertension (Pérez de Ciriza et al., 2015).

Bioclinica Lab employs a manual sandwich immunoassay for the measurement of OPG in serum.

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