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PIIANP // Procollagen Type IIA N-Propeptide

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Type II collagen constitute 60% of cartilage weight and is found exclusively in cartilaginous tissues. Type II pro-collagen is subjected to differential splicing and produces two forms of amino-pro-peptide: PIIANP and PIIBNP, containing respectively the type IIA and type IIB exons (Rousseau, 2004). The IIB form is lacking the domain codded by exon 2: a 69-amino-acid cysteine-rich globular domain (Garnero et al., 2002). PIIANP can be specifically measured and is a biomarker for a collagen type II synthesis (Elsaid and Chichester, 2006; Rousseau, 2004).

Bioclinica Lab employs a manual competitive immunoassay for the measurement of PIIANP in serum.

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