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PINP // Procollagen Type I N-Propeptide

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In bone, type I collagen constitute 90% of the organic matrix. Type I collagen is first synthetized as a type I procollagen and then cleaved at its two extremities. The two cleavage fragments, named N-terminal propeptide of type I collagen (PINP) and carboxy-terminal pro-peptide (PICP) are released and are measurable in blood. Their presence in the peripheral circulation is indicative of bone formation (but not specific)(Garnero et al., 2008; Naylor and Eastell, 2012). PINP is the biomarker of reference for bone formation chosen by The International Osteoporosis Foundation due to its robust nature and dynamic response to treatment (Vasikaran et al., 2011).

Bioclinica Lab employs an automated electro-chemiluminescence immunoassay for the measurement of PINP in serum.


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