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PSA // Prostate Specific Antigen

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Prostate Specific Antigen (PSA) is a member of the Kallikrein related peptidase and is also known as Kallikrein-Related peptidase 3 (KLK3). Its major physiological function is the liquefaction of seminal fluid through its proteolysis activity against gel proteins. PSA is normally found in seminal fluid and only a small proportion is found in blood. The release of PSA in blood circulation is believed to be the result of architecture modification and alterations in the basement membrane when prostate tumors develop (Lilja et al., 2008). In serum, PSA can be bound to α1-antichymotrypsin or α2-macroglobulin or can circulate as free PSA (mixture of mature and pro-, nicked and intact forms of free PSA). In addition to its diagnostic value, PSA levels in serum are measured to monitor treatment response and efficacy (Fleming et al., 2006).

Bioclinica Lab employs an automated sandwich chemiluminescent immunoassay for total PSA measurement in serum.

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