Please Wait...

PTH, Intact // Intact Parathyroid Hormone

Biomarker Therapeutic Areas: 
Biomarker Matrices: 

PTH is produced in the parathyroid gland and is a key regulator in skeletal and mineral homeostasis. PTH is a 84 amino-acid peptide, with an helical conformation in the 1-34 portion of its binding domain to its receptor of type 1 (PTH1R) (Jin et al., 2000). PTH and PTH-related peptide (PTHrP) have highly conserved sequences and activates PTH1R. The C terminal fragments of the intact PTH, PTH(39-84) or PTH(53-84) bind another receptor CPTHR, expressed on bone cells (Divieti et al., 2001). The 1-34 portion of PTH (and the PTHrP) stimulate bone formation and increase bone mass in patients with osteoporosis (Brommage et al., 1999; Lindsay et al., 1997). On the opposite, the truncated PTH 7-34 is a low affinity agonist of the receptor PTHR1 with the C terminus part required for the high affinity binding to the receptor (Gardella et al., 1991; Jin et al., 2000). Since PTH circulates under different forms, biologically active or not, immunoassays for its measurement must be chosen with particular attention (Komaba et al., 2009; Souberbielle et al., 2006).

Several automated or manual sandwich immunoassays are employed in the laboratory for measurement in plasma and/or serum:

  • Second generation assays designed to measure the entire 1-84 amino-acid peptide in addition to the 7-84 amino-acid peptide (Intact PTH or Total PTH),
  • "Third" generation assays which measure only the 1-84 amino-acid peptide (Whole PTH or biologically active PTH) and the Amino-PTH (a post-translational form produced in parathyroid carcinomas).

ADDITIONAL RESOURCES

Biomarker Menu

Download MENU

Molecular Marker Laboratory Services

Download Brochure

Alzheimer's Disease Biomarker Lab Expertise

Download Info Sheet

Leader in Clinical Trial
Management Solutions

Successful clinical trials require the ability to see key details and uncover hidden insights. Bioclinica utilizes science and technology to bring clarity to clinical trials, helping companies to develop new life-improving therapies more efficiently and safely.

RT @bioclinica: @CardiacSafety Consortium needs your feedback! Help make the upcoming think tank "Evaluation of #MobileTechnologies in #CV…
bioclinica (5 minutes ago)
@CardiacSafety Consortium needs your feedback! Help make the upcoming think tank "Evaluation of… https://t.co/0Oc3z6zkO8
bioclinica (10 minutes ago)
RT @CDISC: Special thanks to CDISC Member @bioclinica for hosting CDISC Public Training in Audubon, PA 2-6 Apr 2018. Register today. https:…
bioclinica (26 minutes ago)
Bioclinica Delivers Individual Case Safety Report (ICSR) Processing w Quality & Consistency While Crossing One Mil… https://t.co/77NOME2Dj7
bioclinica (Yesterday)
Who made the BioSpace list of 11 most innovative life sciences companies in the world? Ck it out here via @biospace… https://t.co/f9vtRpsbMW
bioclinica (Yesterday)
BREAKING: With a passion for Drug Safety, we’re delighted to share @bioclinica #pharmacovigilance crossed 1M ICSR c… https://t.co/PAdROjo7tE
bioclinica (2 days ago)

Latest Blogs:

Latin America: Benefit from the Right Partner
Removing Risk from Clinical Trial Management System (CTMS) Implementations
Collaboration Between Clinical Operations and the Logistics and Supply Chain Teams is Key to Trial Success
The Value of Protocol Review
CTMS and RBM: Hot Topics at OCT Nordics in Copenhagen