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sRANKL // Free Soluble Receptor Activator of Nuclear Factor Kappa B Ligand

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Formerly known as TNF-related activation-induced cytokine (TRANCE), the receptor activator of Nf-κB ligand (RANKL) was initially identified as an osteoprotegerin ligand (Lacey et al., 2012). RANKL is a member of the TNF superfamily and exists as a transmembrane protein and in a soluble form (after proteolytic cleavage or alternative mRNA splicing). There are three known spliced variants in human and the smallest of these three variants lacks the transmembrane and the intracellular domain and is directly secreted. The two other variants can be shed and released by proteases (MMP-3, MMP-7, MMP-14, ADAM10, ADAM17 and ADAM19) (Schramek et al., 2010). RANKL, RANK, and osteoprotegerin are a key molecular regulation system for bone remodeling. RANKL is an essential factor for the maturation and survival of osteoclasts. With the Wnt/β-catenin, they are the two major signaling pathway in regulation of bone mass (Boyce and Xing, 2007).

Bioclinica Lab employs two assays to measure RANKL. The assays are designed for the measurement of free RANKL (using recombinant osteoprotegerin for capture and polyclonal antibodies for detection) and total RANKL (sandwich immunoassay) in human serum.

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