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T-tau // Total Tau

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Tau neurofibrillary tangles are one of the two neuropathological features of Alzheimer's disease (with Amyloid plaques). Through its interaction with microtubule protein, Tau is implicated in the neuronal integrity, cellular signaling and axonal transport (Weingarten et al., 1975). In Alzheimer's Disease, there is an increase in Tau phosphorylation which lead to higher cytosolic concentration of Tau (no longer bound to microtubules protein) and subsequently to formation of neurofibrillary tangles (Ballatore et al., 2007; Brandt et al., 2005). An increase in total Tau levels in cerebrospinal fluid is helpful for the diagnosis of Alzheimer's disease (Fagan and Holtzman, 2010; Shaw et al., 2009).

Bioclinica Lab employs a manual sandwich immunoassay for the measurement of Total Tau in human cerebrospinal fluid.

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