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TNF-α // Tumor Necrosis Factor alpha

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Tumor Necrosis Factor α (TNFα) is a pleiotropic cytokine mainly produced by monocytes and macrophages. It was initially found to have a cytotoxic effect on tumor cells and took its name from this. This cytokine exists as a soluble and mature form and as an unprocessed membrane bound form. The soluble form can form an active homo-dimer and an homo-trimer (Barbara et al., 1996; Semenzato, 1990). TNF is shed from the membrane by the metalloprotease ADAM17 (or TACE) and released on the circulation were it can have its central role in the inflammatory response (Gooz, 2010; Old, 1985)

Bioclinica Lab employs a high sensitive manual sandwich immunoassay for measurement of TNFα in serum and synovial fluid.

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