Total iron-binding capacity (TIBC) is the measure of the maximum amount of iron needed to saturate blood transferrin, the main iron-transport protein. TIBC is used as an indirect measurement of transferrin concentrations (Hawkins, 2007; Yamanishi et al., 2003). Patients having iron deficiency display low blood levels of iron but elevated levels of TIBC.
Bioclinica Lab employs a colorimetric method performed in an automated platform for the measurement of TIBC in human serum.
Hawkins, R.C. (2007). Total iron binding capacity or transferrin concentration alone outperforms iron and saturation indices in predicting iron deficiency. Clin. Chim. Acta 380, 203–207.
Yamanishi, H., Iyama, S., Yamaguchi, Y., Kanakura, Y., and Iwatani, Y. (2003). Total Iron-binding Capacity Calculated from Serum Transferrin Concentration or Serum Iron Concentration and Unsaturated Iron-binding Capacity. Clin. Chem. 49, 175–178.