When designing imaging endpoints for clinical trials in Rheumatoid Arthritis, sponsors often consider the use of MRI, which enables the detection of soft tissues for synovial and bone marrow findings in addition to structural damage.
Bioclinica contributes to the advancement of MRI image acquisition for RA studies, helping to deliver high quality clinical trial data in support of MRI endpoints. For example, we guide clinical sites worldwide to improve and standardize scanning techniques through the use of imaging splints which fix anatomical positioning, highlights the wrist and metacarpal anatomy and reduces motion during scanning.
Bioclinica experts have experience with the latest advancements in imaging and scoring systems for inflammatory studies.
Modalities and Endpoints
- Erosions (X-ray, Ultrasound, MRI)
- Inflammation (Doppler)
- Joint space narrowing (X-ray, Ultrasound, MRI)
- Osteitis (Ultrasound, MRI)
- Synovitis (Ultrasound, MRI)
- Tophi (Ultrasound)
- Urate crystal deposits (Ultrasound)
- ASpiMRI-a (with and without Berlin modification), ASpiMRI-c
- Modified Sharp van der Heijde
- Modified Genant
- Modified 7 Joint Ultrasound
- OMERACT-Rheumatoid Arthritis MRI Scoring System (RAMRIS)
- OMERACT-Psoriatic Arthritis MRI Scoring System (PSAMRIS)
- Spodyloarthritis Research Consortium of Canada (SPARCC) MRI index
- Gout Scoring System