Advanced neuroimaging provides sensitive, quantitative and longitudinal information on global and regional structural changes in the brain, informing patient eligibility and drug efficacy of new treatments in clinical trials. Beyond structural data, Molecular imaging (PET) and functional MRI provide clinicians with increasingly sensitive information about brain function, enabling sophisticated evaluation of disease state modifications.
Our neuroscience team has experience with the latest advancements in molecular neuroimaging and biomarkers. Through collaborations with scientists at leading universities, government agencies, and research foundations, Bioclinica continually innovates and develops standardized neuroimaging methodologies for evaluating investigational therapies.
|Angiography||Flutemetamol (Vizamyl) PET|
|ASL-perfusion||Functional MRI (fMRI)|
|CT||Magnetic Resonance Angiography (MRA)|
|CT angiography (CTA)||Magnetization Transfer (MTR)|
|Diffusion Tensor Imaging (DTI)||Perfusion Weighted Imaging (PWI)|
|Diffusion Weighted Imaging (DWI)||Pittsburgh compound (11C-PiB) PET|
|Dopamine Transporter (DaT)||SPECT (DaTscan, In-111 labeled tracers)|
|Florbetapir (Amyvid) PET||Susceptibility Weighted Imaging (SWI)|
|Fluorodeoxyglucose (FDG) PET||Volumetric MRI|
Magnetic Resonance Imaging (MRI)
MRI-based eligibility, safety, and efficacy endpoints play a key role in the design of AD clinical trials.
EXPERTISE IN QUANTITATIVE IMAGE PROCESSING FOR AD TRIALS
- Cross-sectional cortical and subcortical segmentation (Freesurfer based)
- Longitudinal based measurements using Tensor based Morphometry (TBM) and Boundary Shift Integral (BSI)
- Global, regional, and longitudinal changes in cortical thickness
- Quantification of intracranial cavity volume
- Quantification of hyperintense FLAIR/T2 lesions
- Diffusion-Weighted Imaging (DWI) histogram analysis
- Diffusion-Tensor Imaging (DTI) histogram analysis
- Arterial Spin Labeling (ASL) perfusion analysis
- Resting-state and task-based fMRI
Positron Emission Tomography (PET)
Molecular imaging tracers used to visualize amyloid and assess brain function provide key tools for identifying early disease.
MOLECULAR IMAGING TRACERS
- 18F FDG-PET
- 11C PIB
- 18F Florbetapir
- 18F Flutemetamol
- 18F Florbetaben
SITE QUALIFICATION AND TRAINING
- Network of 200+ global PET sites
- On site or remote training
- Use of Hoffman phantom scans
AMYLOID PET OUTCOME MEASURES
- Visual reads
- Quantitative SUVr
- Hybrid visual/quantitative SUVr
- Distribution Volume Ratio (DVR)
FDG-PET OUTCOME MEASURES
- MetaROI: Meta-region assessment (Landau & Jagust)
- Freesurfer-based approaches
- PMOD Alzheimer’s Discrimination Analysis (PALZ)
ABSOLUTE QUANTIFICATION FOR NOVEL PET TRACERS
- Dynamic PET acquisition
- Blood sampling standardization
- Kinetic analysis and modeling
Bringing together atlas-based brain segmentation and registration-based atrophy quantification for accurate and reliable volumetric analysis for clinical trials.
Whole brain, ventricles, hippocampus, entorhinal cortex as well as cortical and subcortical segmentation is performed using cross-sectional Freesurfer. Multi-atlas segmentation techniques can also be used for alternative brain parcellation. In particular, our system supports the use of the Harmonized Hippocampus Protocol.
Tensor-Based Morphometry-Jacobian Integration (TBM-JI) and Boundary Shift Integration (BSI) are used to quantify Brain, Hippocampal and Ventricular atrophy with high reproducibility.
Functional MRI (fMRI)
Initiatives to improve the standardization of fMRI acquisition, processing, and analysis are facilitating its implementation as a primary or exploratory endpoint in large, multi-center clinical trials. BioClinica has expertise with task-based and resting-state fMRI, with a focus on standardized capabilities for clinical trials.
- Deployment across major vendors (GE, Philips, and Siemens) at both 1.5T and 3T
- Deployment across expert academic centers as well as standalone clinical imaging facilities
- Standardization across sites and optimizati on at each site
- Experience with many types of cognitive tasks, facilitating standardization of stimulus presentation across sites
- Behavioral responses (for task-based fMRI) and physiological recordings
- fMRI time series and additional sequences for image processing and analysis (high-resolution structural imaging, field mapping)
- Technologist training (remote or on-site)
- Site qualification including phantom scanning (including both static and temporal stability evaluation) and/or in vivo testing
- In-depth quality assessment and site feedback with fast turnaround
PROCESSING, ANALYSIS, AND REPORTING
- 100% automated preprocessing stream including motion correction, distortion correction, registration to anatomical space, segmentation and parcellation
- For resting-state fMRI, the complete connectivity matrix reports functional relationships between all brain regions (seed-based and ICA approaches also possible)
- For task-based fMRI, General Linear Models (containing predictors of interest and nuisance regressors) are estimated to derive the effects of a task