As the world's foremost imaging core lab, Bioclinica brings over 30 years of clinical trial experience and medical imaging services for advancing neuroscience clinical trials. Our therapeutically-aligned neuroscience team provides targeted expertise and high quality results.
Bioclinica has extensive experience with neuroscience clinical trials, providing comprehensive support for clinical studies across a wide range of neuroscience indications.
|Acromegaly||Mild Cognitive Impairment|
|Alzheimer's Disease||Multiple Sclerosis|
|Brain Tumors||Neurovascular Stroke|
|CADASIL||Neurovascular Stroke Devices|
|CNS Contrast Agents||Parkinson's Disease|
|Creutzfeldt-Jakob Disease||Prodromal Alzheimer's disease|
|Cushing's Disease||Spinal Cord Injury|
|Frontotemporal Dementia||Vascular Dementia|
Alzheimer's disease (AD)
Alzheimer's disease (AD) is the most common cause of dementia, affecting almost 50% of the population over the age of 85, and costing the US economy over $100 billion per year. Although there are several FDA approved drugs for treatment of AD, current drugs are designed to treat AD symptoms with minimal impact on the long term course of disease. Furthermore, there are no treatments available which have been shown to slow the progression of AD.
Numerous clinical trials aimed at slowing the progression of AD are in progress, and many more are expected in the near future, facilitated by advances in our understanding of the underlying pathophysiological mechanisms of the disease. Newer AD treatments include agents which reduce the amount of beta amyloid in the brain, reduce oxidative injury (providing neuroprotection), inhibit necrosis or apoptosis, stimulate the growth of new neurons, or promote dendritic sprouting of existing neurons.
Quantitative methods for measuring progressive brain atrophy using structural MRI are considerably more complex than routine clinical evaluation of brain scans by radiologists, requiring specialized imaging equipment, specific acquisition sequences and highly specialized neuroimaging analysis software tools.